RETIX.C Resteeme® – Injectable Bioregeneration Line
Resteeme is a new generation of injectable bioregenerators, created under the Retix.C brand by URGO Group – a global expert with over 60 years of experience in wound healing, skin regeneration, and improvement of skin structure.
The philosophy behind Resteeme is stimulation of the skin’s natural regenerative mechanisms. Treatments are designed to deliver subtle, natural results without exaggerated effects, meeting the growing demand for therapies that respect skin physiology.
The Resteeme line includes 3 innovative injectable products – Resteeme X, Resteeme L and Resteeme H – distinguished from market competitors by their more intense, longer-lasting and multi-directional action compared to previously known biostimulators.
Science & Technology
At the heart of Resteeme lies a patented combination of hyaluronic acid and trehalose (U.S. Patent No. 2021/0315804 A1).
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Hyaluronic Acid (HA): Known for stimulating fibroblast proliferation, antioxidant and anti-inflammatory activity, and protection against oxidative stress (anti-AGEs effect).
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Trehalose: Protects HA from enzymatic degradation, extends its longevity, and enhances antioxidative defence.
This synergy has been clinically shown to reduce the formation of advanced glycation end-products (AGEs) by 45% under baseline conditions and maintain protection even under induced glycation stress.
Unique Triple Effect
RETIX.C Resteeme delivers three synergistic benefits in one line:
Biorevitalisation
improved skin quality, hydration, smoothness and illumination
Bioregeneration
up to 44% more effective and up to 54% longer lasting than leading products on the market.
Bioreconstruction
lifting effect without unnatural, exaggerated effects
Expert Behind Resteeme
Robert Chmielewski, MD – Surgeon, Aesthetic Medicine Physician
Dr. Robert Chmielewski is one of the leading experts involved in the formulation and clinical evaluation of the Resteeme line. With extensive experience in aesthetic and regenerative medicine, he played a key role in designing treatment protocols and validating the efficacy of the patented hyaluronic acid and trehalose combination used in Resteeme X.
As the principal investigator of the clinical and instrumental studies, Dr. Chmielewski demonstrated that Resteeme provides measurable and long-lasting results:
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+0.07 mm increase in skin thickness within 8 weeks confirmed by ultrasound.
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45% reduction in red areas and 68% reduction of UV spots after the first treatment.
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41% reduction in visible pores and 75% reduction in red spots after three treatments.
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Anti-glycation effect confirmed in laboratory studies: a 45% reduction of AGE (CML) formation under baseline conditions and a 30% reduction under glycation stress, proving the protective power of HA + trehalose against skin ageing processes.
Dr. Chmielewski continues to contribute to advancing regenerative aesthetics, confirming the safety and effectiveness of Resteeme even on thin and delicate skin, and highlighting its natural, patient-loved rejuvenation effect.
X-treme Technology:
Wide Spectrum HA Chains
Resteeme products combine low, medium, and high molecular weight hyaluronic acid:
1
Low MW
(200–400 kDa)
fibroblast stimulation, collagen & elastin synthesis.
2
Medium MW
(1000–1500 kDa)
hydration and regeneration acceleration.
3
High MW
(1800–2600 kDa)
antioxidant & anti-inflammatory effect, lifting and modeling.
3 Products for Personalized Protocols
RETIX.C Resteeme injectables can be used individually or in combination to tailor treatment depth and intensity. Recommended series: 3 treatments every 1–4 weeks, depending on patient needs and physician assessment. Suitable for patients of all ages, both women and men.
Resteeme Protocols
A series of 3 sessions performed every 1–4 weeks, depending on the chosen administration technique, product type, indications and physician’s assessment. Effects accumulate with each session, providing visible and lasting improvement in skin quality.
Administration techniques include:
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Nappage or R-PEN technique – superficial application.
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Micropapular injections – superficial or medium-deep intradermal administration.
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RTDI (Retrotracing Diagonal Injection) – medium-deep intradermal administration.
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Deep technique – precise points supporting the face oval for a natural lifting effect.
Resteeme protocols are suitable for patients of different ages, both women and men, and can be integrated into broader treatment plans for anti-ageing and regenerative medicine.
Click to see detailed protocols with video recordings from training in Vilnius (access for registered clients only)