FILLMED NCTF® 135 HA – The Iconic Regenerative Solution for Skin Quality
NCTF® 135 HA is an injectable polyrevitalizing solution containing 60 essential ingredients that create an optimal cellular environment for fibroblast activity and natural collagen stimulation.
A reference product in skin regeneration for over 45 years, backed by extensive clinical evidence and worldwide medical use.
Most Comprehensive Polyrevitalizing Formula on the Market
The synergistic blend of 60 biologically active components creates an optimal cellular environment for dermal regeneration, enhancing fibroblast activity, collagen production, and overall skin quality from within. This complete formulation delivers immediate hydration and long-term structural improvement, adapting seamlessly to various skin conditions and treatment indications.
1
Bio-Stimulation Potential
Fibroblast Activation: the ability of the 60-ingredient formula to stimulate fibroblasts and support physiological collagen synthesis. This promotes continuous dermal renewal and contributes to visibly improved skin quality over time.
2
Skin Density Potential
Collagen Support: the capacity of the formula to provide essential amino acids, co-enzymes, vitamins, and nucleosides required for optimal collagen metabolism. This helps reinforce dermal structure, enhancing firmness and improving overall tissue quality.
3
Radiance Potential
Immediate Glow: the rapid effect of the polyrevitalizing complex on hydration and skin vitality, resulting in a fresher, more luminous appearance after each session. This ensures a natural-looking radiance and enhances visible skin smoothness.
Fibroblast Activation & Collagen Induction
Ageing reduces fibroblast activity, ECM quality and collagen structure. NCTF® 135 HA provides the essential elements required at every step of collagen synthesis, enabling physiological neocollagenesis and long-term dermal redensification.
Key Findings
+256% collagen stimulation (in vitro)¹
+148% fibroblast stimulation (in vitro)¹
+54% dermis density (in vivo) after 3 sessions (HEBE2 Study)²
+69% skin tonicity (clinical evaluation)³
Immediate & Long-Term Patient Benefits
1. Immediate glow after the first session⁴
2. Smoothing effect:
–40% crow’s feet⁵
–50% cheek folds⁵
–32% necklines (HEBE3 Study)⁵
3. Tightening and redensification maintained up to 4 months²
4. Suitable for face, neck, décolleté and all ageing skin areas⁴
Formula: 60 Essential Ingredients for Optimal Cellular Function
Unique, complete, and physiologically balanced injectable
Free Hyaluronic Acid — 5 mg/mL
High molecular weight HA (700–1300 kDa), similar to filler-grade HA
Key roles:
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Activates CD44 receptors on fibroblasts
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Retains water for immediate plumping
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Supports extracellular matrix structure
Glutathione
Powerful tripeptide antioxidant working synergistically with vitamins C and E.
Key roles:
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Reduce oxidative stress
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Enhance antioxidant defenses
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Support gentle, well-tolerated dermal revitalization
12 Vitamins
Retinol (A), Thiamine (B1), Riboflavin (B2), Niacin (B3), Pantothenic Acid (B5), Pyridoxine (B6), Biotin (B8), Inositol (B7), Folic Acid (B9), Cyanocobalamin (B12), Ascorbic Acid (C), Tocopherol (E).
Key roles:
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Support metabolic reactions essential for collagen formation
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Provide antioxidant protection
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Regulate cellular activity and stabilize protein structures
24 Amino Acids
Alanine, Arginine, Asparagine, Aspartic Acid, Cystine, Glutamine, Glutamic Acid, Glycine, Histidine, Hydroxyproline, Isoleucine, Leucine, Lysine, Methionine, Ornithine, Phenylalanine, Proline, Serine, Taurine, Threonine, Tryptophan, Tyrosine, Valine, γ-Aminobutyric Acid (GABA).
Key roles:
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Build collagen and elastin fibers
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Support dermal structure and ECM integrity
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Maintain fibroblast metabolic activity
5 Nucleosides
Deoxyadenosine, Deoxycytidine, Deoxyguanosine, Deoxythymidine, 5-Methyl-2’-deoxycytidine.
Key roles:
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Regulate gene expression linked to ECM production
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Support fibroblast proliferation
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Enable efficient protein synthesis
6 Co-enzymes
TPP, CoA, FAD, NAD, NADP, UTP.
Key roles:
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Regulate cellular metabolic pathways
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Enable efficient collagen formation
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Support intracellular energy production
6 Minerals
Calcium Chloride, Potassium Chloride, Magnesium Sulphate, Sodium Acetate, Sodium Chloride, Sodium Dihydrogenophosphate.
Key roles:
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Maintain cell homeostasis and membrane permeability
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Support collagen fibril organization
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Promote cell proliferation and differentiation
Compatible Procedures
Dermal Fillers:
Helps improve skin hydration and elasticity, enhancing the natural integration of fillers and supporting longer-lasting aesthetic outcomes.
Botulinum Toxin:
Optimises the skin environment, complementing wrinkle-relaxing effects and contributing to a smoother, more uniform skin surface.
Laser Treatments:
Supports dermal regeneration before and after energy-based procedures, aiding in improved recovery and better textural refinement.
Peels:
Enhances post-peel results by reinforcing hydration and restoring essential dermal elements for a brighter, more even complexion.
Microneedling / Fractional Techniques:
Delivers key ingredients directly where they are needed, amplifying collagen-stimulating effects and promoting structural skin improvements.
Combining NCEF 135 HA with other treatments was tested and analysed in various clinical studies:
FILLMED Signature Protocols
The FILLMED Signature Protocols with NCTF® 135 HA are advanced skin quality treatment strategies designed to deliver targeted polyrevitalization through precise intradermal techniques. These protocols combine the potential of NCTF®’s 60-ingredient complex with structured injection methods to improve radiance, hydration, density, and overall skin vitality. Each protocol is tailored to address specific clinical indications and enhance aesthetic outcomes, providing natural-looking skin rejuvenation results.
BEAUTIFEYE
The FILLMED signature protocol BEAUTIFEYE is a targeted rejuvenation treatment for the eye contour, using NCTF® 135 HA to improve hydration, smooth fine lines, and brighten the delicate periocular area. Precise intradermal techniques help refresh tired-looking eyes and enhance overall radiance with natural-looking results.
NANOSOFT® – safe and precise injections
NANOSOFT® is an advanced intradermal delivery device engineered to elevate skin quality treatments. Its ultra-short triple microneedle design enables controlled, comfortable, and reliable application of NCTF® 135 HA, especially in delicate areas such as the periocular region.
Optimised Anatomical Safety
Superficial 0.6 mm depth: the ultra-short microneedles are designed to reach only the upper dermis, reducing the risk of going too deep and allowing safe treatment of sensitive zones like the eye contour and neck.
High Patient Comfort
Silicone-coated micro-needles: significantly reduce treatment sensation, providing a gentler, more tolerable experience compared to classic 30G–32G intradermal needles.
Enhanced Injection Stability
Triple-needle structure: the three-point configuration increases device stability on the skin surface, helping practitioners maintain steady control and achieve cleaner, more uniform injections across each treatment area.
Scientific Basis
¹ Polycomponent mesotherapy formulations for the treatment of skin ageing and improvement of skin quality, Sergey Prikhnenko, Clinical, Cosmetic, Investigational Dermatology 2015:8 151–157. Results obtained on NCTF® powder.
² Clinical trial of 3 sessions of NCTF® 135 HA on healthy volunteers, 2019. Randomized controlled study, multicenter (10 centers) and prospective study. 147 subjects included. 3 sessions spaced out by 21 days on face, neck & décolleté. Clinical scoring + instrumental measures (HEBE2 Study).
³ Results after 3 sessions – Clinical evaluation of efficacy of 5 sessions of NCTF® 135 HA on healthy volunteers, 2011. Open, multicenter (16 centers) and prospective study. 40 subjects included. 3 sessions spaced out by 15 days and 2 sessions by 30 days. Clinical scoring.
⁴ Immediate glow & long-term activation data (NCTF® 135 HA) – as presented in A4-ADV-BRO-REGENERATION-FM-EXT.
⁵ Comparative split face and neck clinical trial on NANOSOFT® versus classic needle for anti-ageing effects of NCTF® 135 HA on 40 healthy volunteers, 2019. Randomized controlled study, monocenter and prospective study. 3 sessions spaced out by 21 days on face & neck. Clinical scoring + instrumental measures (HEBE3 Study).